In 2007, Physiome.jp was founded by the MEXT Global Center of Excellence program “In Silico Medicine-Oriented Worldwide Open Platform” at Osaka University (Leader: Prof. Taishin Nomura, Osaka University, 2007–2011). Physiome.jp was supported by Osaka University in the period of April 2007 to March 2013.
Since April 2013, the site was taken over by Professor Hiroaki Kitano and Dr. Yoshiyuk Asai, and supported by Open Biology Unit, Okinawa Institute of Science and Technology Graduate University, which was renamed to Integrated Open Systems Unit since April 2015.